Chemistry Matters — Bioprospecting: Hunting for Natural Products

Most people know the names of the common classes of biomolecules—proteins, carbohydrates, lipids, and nucleic acids—but there are many more kinds of compounds in living organisms than just those four. All living organisms also contain a vast diversity of substances usually grouped under the heading natural products. The term natural product really refers to any naturally occurring substance but is generally taken to mean a so-called secondary metabolite—a small molecule that is not essential to the growth and development of the producing organism and is not classified by structure.

Figure 5.16 Rapamycin, an immunosuppressant natural product used during organ transplants, was originally isolated from a soil sample found on Rapa Nui (Easter Island), an island 2200 miles off the coast of Chile known for its giant Moai statues. (credit: modification of work “Moai facing inland at Ahu Tongariki” by Ian Sewell/Wikimedia Commons, CC BY 2.5)

It has been estimated that well over 300,000 secondary metabolites exist, and it’s thought that their primary function is to increase the likelihood of an organism’s survival by repelling or attracting other organisms. Alkaloids, such as morphine; antibiotics, such as erythromycin and the penicillins; and immunosuppressive agents, such as rapamycin (sirolimus) prescribed for liver transplant recipients, are examples.

Where do these natural products come from, and how are they found? Although most chemists and biologists spend their working time in the laboratory, a few spend their days scuba diving on South Pacific islands or trekking through the rainforests of South America and Southeast Asia at work as bioprospectors. Their job is to hunt for new and unusual natural products that might be useful as drugs.

As noted in the Chapter 3 Chemistry Matters, more than half of all new drug candidates come either directly or indirectly from natural products. Morphine from the opium poppy, prostaglandin E1 from sheep prostate glands, erythromycin A from a Streptomyces erythreus bacterium cultured from a Philippine soil sample, and benzylpenicillin from the mold Penicillium notatum are examples. The immunosuppressive agent rapamycin, whose structure is shown previously, was first isolated from a Streptomyces hygroscopicus bacterium found in a soil sample from Rapa Nui (Easter Island), located 2200 miles off the coast of Chile.

With less than 1% of living organisms yet investigated, bioprospectors have a lot of work to do. But there is a race going on. Rainforests throughout the world are being destroyed at an alarming rate, causing many species of both plants and animals to become extinct before they can even be examined. The governments in many countries seem aware of the problem, but there is as yet no international treaty on biodiversity that could help preserve vanishing species.